A 54-year-old woman who has been diag- nosed with early-stage breast cancer undergoes surgery for a lumpectomy to remove a small tumor detected by mammography. The pathology report confirms the early stage of the cancer and further comments on the fact that there is significant desmoplasia in the surrounding tissue. The term desmoplasia refers to

(a)  An irregular accumulation of blood vessels
(B)  Maturation and spatial arrangement of cells
(C)  Metastatic involvement of surrounding tissue.
(d)  Proliferation of non-neoplastic fibrous connective tissue.

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